Splice to discover
Splice to understand

Deciphering the complexity of the transcriptome to illuminate cell physiology and disease pathology.

Our Products

Transcript
switching

Antisense OligoNucleotides for switching target transcript to an alternate splice-isoform
  • Modulation of specific splice event
  • Transcript-specific switching
  • Phenotype-based validation of targets
  • Pathway-centric and gene-family options
  • Covers major types of splicing patterns

Example Paper

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
Georgilis et al. 2018. Cancer Cell

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knock-down

Antisense OligoNucleotides for target transcript knockdown
  • Induction of RNase H degradation
  • Transcript-specific knockdown
  • Phenotype-based validation of targets
  • Pathway-centric and gene-family options
  • Overcomes off-target issues (e.g. siRNA)

Example Paper

Gapmer, siRNA, SSO and their effects on transcript knockdown efficiency
Bin Muzakar et al. 2021. Manuscript in preparation

Transcript
knock-down

Antisense OligoNucleotides for target transcript knockdown
  • Induction of Nonsense-Mediated Decay (NMD)
  • Transcript-specific knockdown
  • Phenotype-based validation of targets
  • Pathway-centric and gene-family options
  • Overcomes off-target issues (e.g. siRNA)

Example Paper

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
Koh et al. 2015. Nature

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NOA-Switch™

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NOA-GAPmer™

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NOA-NMD™

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Antisense OligoNucleotides

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Transcriptome coverage